Cannondale Synapse Carbon Owner's Manual - page 23
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Your bicycle may be equipped with a different securing method for the front wheel than for the rear wheel.
Discuss the wheel securing method for your bicycle with your dealer.
It is very important that you understand the type of wheel securing method on your bicycle, that you know
how to secure the wheels correctly, and that you know how to apply the correct clamping force that safely
secures the wheel.
Ask your dealer to instruct you in correct wheel removal and installation, and ask for the manufacturer’s
instructions.