F-SECURE ANTI-VIRUS - FOR MICROSOFT EXCHANGE Administrator's Manual - page 204
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3.8.3
Notifications
If end-users in the organization use other than
Microsoft Outlook e-mail client to send and
receive e-mail, it is recommended to specify all
end-user workstations as Internal SMTP
Senders.
If the organization has Exchange Edge and Hub
servers, the server with the Hub role installed
should be added to the Internal SMTP Sender
on the server where the Edge role is installed.
IMPORTANT: Do not specify the server where
the Edge role is installed as Internal SMTP
Sender.